A Rare Case: Amegakaryocyte Trombocytopenia As Early Manifestation Of Juvenile Systemic Lupus Erythematosus

Authors

  • Yeni Amalia
  • Wisnu Barlianto Susanto Nugroho

DOI:

https://doi.org/10.33474/jki.v9i2.8886

Keywords:

A rare case of amegakaryocyte thrombocytopenia in juvenila SLE has been successfully diagnosed. Key word, child, girl, SLE, AMT

Abstract

ABSTRACT

BACKGROUND Systemic lupus erythematosus (SLE) is a chronic autoimmune disease which results in inflammation and eventual damage in a broad range of organ systems. Trombocytopenia is a common complication in patients with SLE, but amegakaryocyte trombocytopenia (AMT) is a rare disorder in SLE that characterized by isolated thrombocytopenia as a consequence of a marked decrease in or total absence of megakaryocytes in an otherwise normal bone marrow.

CASE Lu, a wellnourished 13 y.o girl, complaining for high fever for 2 weeks, diminished body weight, artralgia, furunculosis, oral apthae and palour for 1 year, and bruising extremities for 2 motnhs. There was hepatosplenomegali. Laboratory findings: Hb 8.8 gr/dL, hct 27%, leucocytes 1.000/µL (ANC 230/µL), trombocytes 25,000/µL. Bone marrow puncture revealed amegacaryocyte thrombocytopenia, absence of megacaryocyte while erythropoesis and granulopoesis were normal. Anti ds DNA 223.8 iu/ml (+); ANA test 101.7 unit (+), microalbumin urine 10 mcg/mg (-), C3 complement 40 mg/dL (¯), ACA IgM 20.6 U/ml (+), ACA IgG 17.3 U/mL (+). The case fulfilled 5 criteria of ACR for SLE. The patient administered ceftazidim and gentamycin for febrile neutropenia, and high dose methylprednisolon injection for SLE.

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Published

2020-09-24

Issue

Vol. 9 No. 2 (2020): Jurnal Kesehatan Islam : Islamic Health Journal

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