Efek Pemberian Ekstrak Etanol Daun Jarak Merah (Jatropha gossypiifolia L.) terhadap Kadar Glukosa Darah Puasa, Kadar Insulin Serum dan HOMAIR pada Model Tikus DM Tipe 2

Authors

  • Nugroho Wibisono
  • Achmad Basori
  • Suhartati

DOI:

https://doi.org/10.33474/jki.v11i2.19225

Abstract

Abstract. Jatropha gossypiifolia L. is a medicinal plant from the
Euphorbiaceae family. Jatropha gossypiifolia L. leaves have some
medicinal properties, but their effect on antidiabetics mechanisms is
still unclear. Jatropha gossypiifolia leaves have some active
compounds such as alkaloid, flavonoid, phenol, saponins, tannins,
steroid, terpenoid, and triterpenoid. The presentstudy was designed
to analyze effect of Jatropha gossypiifolia leaves extract active
compounds on fasting blood glucose levels, serum insulin levels and
HOMA-IR. The design of thisresearch istrue experimental with posttest only control group design with independent variables including
a high-fat diet, streptozotocin injections, Jatropha gossypiifolia L.
leaves extract in doses of 60, 120, dan 240 mg/kg and dependent
variables including fasting blood glucose levels, serum insulin levels,
and HOMA-IR. Based on this study, there were a significantly
different between fasting blood glucose levels and HOMA-IR control
groups than the extract groups. It can be concluded that Jatropha
gossypiifolia L. leaves extract has effect on fasting blood glucose
levels, serum insulin levels and HOMA-IR on DM type 2 rat models.

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Published

2023-02-06