PENGARUH VARIASI PRIMOGEL SEBAGAI DISINTEGRAN TERHADAP MUTU FISIK TABLET KITOSAN CANGKANG KEPITING BAKAU (Scylla serrata) DARI CO-PROCESSED EXCIPIENT

Abstract

Abstract. Mud crab shells contain chitin which can be converted into chitosan. Co-processed excipient or combining two or more excipient ingredients can increase the compressibility, compactibility of tablets. This research aims to formulate the active ingredient chitosan which is synthesized from mangrove crab (Scylla serrata) shells and then make chitosan tablets with a co-processed excipient consisting of two variations of primogel. The difference in formula, namely F1 (primogel 4%) and F2 (primogel 8%) was then seen as to its effect on the physical quality of the tablet. The tablet printing method is direct compression. The physical quality of the tablets was evaluated and the results showed that the formula met the test requirements for tablet weight uniformity, friability, hardness, disintegration time but did not meet the requirements for tablet size uniformity. Then the evaluation results of the co-processed excipient met the specifications for the flow speed test, angle of repose, compressibility index, Hausner ratio, water content test and particle size distribution. Thus, it can be concluded that chitosan from mangrove crab shells (Scylla serrata) can be formulated into tablet preparations from co-processed excipients using the direct compression method but there is no significant difference between Primogel 4% and 8% as a crushing agent on the characteristics of chitosan tablets. mud crab (Scylla serrata) shell.

Kata Kunci:

Chitosan; Co-processed Excipients; Primogel; Scylla serrata ;Tablets